Zanki — Step 1 Coverage Audit
The Zanki Step 1 deck covers 81.9% of the USMLE Step 1 content outline — 738 out of 901 canonical subtopics — making it one of the most comprehensive free Anki resources available for Step 1 prep. For most students, Zanki alone is not enough, but it gets you further than almost any other single deck. The 163 complete gaps and 120 thin spots (1–3 cards) mean targeted supplementation is essential, not optional.
Zanki (JF Update) contains 18,388 total cards, with 18,345 mapped to Step 1 subtopics. It was built by aggregating Zanki's original content with updates from the medical school Anki community, and it's the default starting deck for a large portion of Step 1 studiers. Its strongest systems are Biochemistry (96.4% coverage, 3,715 cards), Renal (93.0%, 1,589 cards), and Gastrointestinal (90.5%, 1,897 cards). If you need dense, well-tested content in those areas, Zanki delivers. The weakest areas are General Pharmacology (30.6% coverage, only 117 cards across 36 subtopics), Microbiology (70.0%), and Psychiatry (72.0%) — these are the systems where relying on Zanki alone will leave real holes on exam day.
This page is the only independent coverage audit of the Zanki Step 1 deck mapped against the full 901-subtopic USMLE Step 1 outline. The data here identifies exactly which subtopics have zero cards — including high-yield gaps like Chemical Mediators of Inflammation, Phases of Wound Healing, HBV Serology Patterns, and Adrenergic Agonists (Direct) — so you can study smarter instead of discovering gaps during practice blocks.
Step 1 cards = cards that mapped to our 901-subtopic Step 1 content outline. Cards covering other material are excluded.
Coverage by area
| Area | Coverage | Cards |
|---|---|---|
| Biochemistry | 53/55 (96.4%) | 3,715 |
| Renal | 53/57 (93.0%) | 1,589 |
| Gastrointestinal | 67/74 (90.5%) | 1,897 |
| Hematology and Oncology | 55/61 (90.2%) | 1,374 |
| Neurology and Special Senses | 53/59 (89.8%) | 2,773 |
| Endocrine | 46/53 (86.8%) | 1,322 |
| Cardiovascular | 55/64 (85.9%) | 2,250 |
| Immunology | 28/33 (84.8%) | 492 |
| Musculoskeletal, Skin, and Connective Tissue | 61/72 (84.7%) | 1,634 |
| Public Health Sciences | 25/30 (83.3%) | 425 |
| Reproductive | 64/80 (80.0%) | 1,573 |
| General Pathology | 21/27 (77.8%) | 144 |
| Respiratory | 50/65 (76.9%) | 1,642 |
| Psychiatry | 54/75 (72.0%) | 604 |
| Microbiology | 42/60 (70.0%) | 271 |
| General Pharmacology | 11/36 (30.6%) | 117 |
| Total | 738/901 (81.9%) | 18,345 mapped |
Gaps — zero cards (163 subtopics)
High-yield gaps
- HYFermentation and NAD+ RegenerationBiochemistry
- HYNSTEMI Risk Stratification and TimingCardiovascular
- HYRight Ventricular InfarctionCardiovascular
- HYAdrenergic Receptors and AgonistsCardiovascular
- HYOsteoporosisEndocrine
- HYOsteoporosis PharmacotherapyEndocrine
- HYHBV Serology PatternsGastrointestinal
- HYProton Pump InhibitorsGastrointestinal
- HYChemical Mediators of InflammationGeneral Pathology
- HYPhases of Wound HealingGeneral Pathology
- HYBenign vs Malignant NeoplasiaGeneral Pathology
- HYP450 Inducers and InhibitorsGeneral Pharmacology
- HYCholinergic Agonists (Direct and Indirect)General Pharmacology
- HYCholinergic Antagonists (Muscarinic Blockers)General Pharmacology
- HYAdrenergic Agonists (Direct)General Pharmacology
- HYAcetaminophen Toxicity and NACGeneral Pharmacology
- HYSedative and Opioid ReversalGeneral Pharmacology
- HYAnticoagulant ReversalGeneral Pharmacology
- HYHeparin-Induced Thrombocytopenia (HIT)Hematology and Oncology
- HYAntitumor AntibioticsHematology and Oncology
- HYComplement Functions and RegulationImmunology
- HYEncapsulated OrganismsMicrobiology
- HYBacterial ExotoxinsMicrobiology
- HYEndotoxin (LPS) and Septic ShockMicrobiology
- HYStreptococcus pneumoniaeMicrobiology
- HYStreptococcus pyogenes (Group A Strep)Microbiology
- HYListeria monocytogenesMicrobiology
- HYLyme Disease (Borrelia burgdorferi)Microbiology
- HYToxoplasma gondiiMicrobiology
- HY50S Ribosomal InhibitorsMicrobiology
- HYNucleic Acid Synthesis InhibitorsMicrobiology
- HYDMARDs and BiologicsMusculoskeletal, Skin, and Connective Tissue
- HYParkinson Disease PharmacotherapyNeurology and Special Senses
- HYBipolar II DisorderPsychiatry
- HYSchizoaffective DisorderPsychiatry
- HYAtypical Antidepressants (Bupropion, Mirtazapine, Trazodone)Psychiatry
- HYValproate as Mood StabilizerPsychiatry
- HYAtypical (Second-Generation) AntipsychoticsPsychiatry
- HYBenzodiazepinesPsychiatry
- HYACE Inhibitors and ARBs — Renal EffectsRenal
- HYSERMs (Tamoxifen, Raloxifene)Reproductive
- HYβ2-Agonists (SABA / LABA)Respiratory
- HYInhaled and Systemic CorticosteroidsRespiratory
Other gaps
- Protein-Energy MalnutritionBiochemistry
- Takotsubo (Stress) CardiomyopathyCardiovascular
- Vasospastic (Prinzmetal) AnginaCardiovascular
- Cocaine-Induced Chest Pain / MICardiovascular
- Acute Limb IschemiaCardiovascular
- Syncope (Cardiac, Vasovagal, Orthostatic)Cardiovascular
- Cholinergic Receptors and AgentsCardiovascular
- Paget Disease of BoneEndocrine
- MODY (Maturity-Onset Diabetes of the Young)Endocrine
- Alpha-Glucosidase Inhibitors and OthersEndocrine
- … and 110 more
Thin spots — 1 to 3 cards (120 subtopics)
- 1Post-MI Arrhythmia and ICD IndicationsCardiovascular
- 1ACS Antiplatelet and Anticoagulant TherapyCardiovascular
- 1Pulmonary HypertensionCardiovascular
- 1Cushing Disease (ACTH-Secreting Pituitary Adenoma)Endocrine
- 1Thyroid Emergencies (Storm and Myxedema Coma)Endocrine
- 1Hyperosmolar Hyperglycemic State (HHS)Endocrine
- 1VIPoma (Verner-Morrison Syndrome)Endocrine
- 1Sulfonylureas and MeglitinidesEndocrine
- 1MetforminEndocrine
- 1Thiazolidinediones (TZDs)Endocrine
- … and 110 more
How to pair Zanki with other resources
The biggest holes in Zanki are in General Pharmacology, Microbiology, and Psychiatry — and your pairing strategy should target those first. For General Pharmacology (30.6% coverage), Boards & Beyond pharmacology lectures paired with a dedicated pharm deck like Pepper Pharm will fill the mechanism and receptor content Zanki skips entirely, including Adrenergic Agonists (Direct), which has zero Zanki cards despite being high-yield. For Microbiology (70.0%), Sketchy Micro remains the standard supplement — Zanki's 271 cards across 42 subtopics leave 18 microbiology subtopics completely uncovered. For Psychiatry (72.0%), First Aid reading plus targeted UWorld questions will patch the 21 uncovered subtopics more efficiently than hunting for add-on decks.
For the gaps in General Pathology — specifically Chemical Mediators of Inflammation and Phases of Wound Healing, both at zero cards — Pathoma is the direct fix. Watch the relevant Pathoma chapters and make your own cards or pull from a Pathoma-specific deck. The Cardiovascular gaps (NSTEMI Risk Stratification, Right Ventricular Infarction) and the Endocrine gaps (Osteoporosis, Osteoporosis Pharmacotherapy) are best addressed through Boards & Beyond videos and active UWorld review, where the clinical vignette format forces retention better than passive cards for these reasoning-heavy subtopics.
Frequently asked questions
Is Zanki enough for Step 1?
Zanki covers 81.9% of the USMLE Step 1 content outline (738 out of 901 subtopics), making it a strong foundation but not a complete resource on its own. It has 163 subtopics with zero cards and 120 with only 1–3 cards, including high-yield gaps in General Pharmacology, Microbiology, and Psychiatry. Most students who score well pair Zanki with Boards & Beyond, Pathoma, and Sketchy to close those gaps.
How many cards are in Zanki?
The Zanki (JF Update) deck contains 18,388 total cards, of which 18,345 are mapped to USMLE Step 1 subtopics and 12 are out of scope. It is one of the largest single Anki decks available for Step 1 prep. Card density varies significantly by system — Biochemistry alone accounts for 3,715 cards, while Microbiology has only 271.
What does Zanki not cover for Step 1?
Zanki has 163 completely uncovered Step 1 subtopics, with the worst gaps in General Pharmacology (only 30.6% of subtopics covered), Microbiology (70.0%), and Psychiatry (72.0%). Specific high-yield zero-card gaps include Chemical Mediators of Inflammation, Phases of Wound Healing, HBV Serology Patterns, Proton Pump Inhibitors, and Adrenergic Agonists (Direct). These are not obscure topics — several appear repeatedly in UWorld and on Step 1.
What is the weakest system in the Zanki Step 1 deck?
General Pharmacology is by far the weakest system in Zanki, covering only 11 of 36 subtopics (30.6%) with just 117 cards — the lowest coverage rate of any system in the deck. Microbiology (70.0%, 42/60 subtopics) and Psychiatry (72.0%, 54/75 subtopics) are the next weakest. Students relying on Zanki for pharmacology are missing more than two-thirds of the tested content outline in that system.